Preheat oven to 425 degrees Fahrenheit. Line a rimmed baking sheet with parchment paper.
In a large mixing bowl, whisk together the flour, paprika, garlic powder, onion powder, kosher salt, ground pepper, and cayenne pepper until well combined. Add the milk and whisk together to create a slurry. This will be the batter to coat the cauliflower.
Cut florets into pieces and add to the prepared batter. Using a spoon, mix to evenly coat every cauliflower bite in the batter. Pour out the cauliflower bites on the parchment lined baking sheet and spread them out evenly so they're not too close together to help them crisp up and brown.
Roast the cauliflower for 25 minutes, flipping them halfway, until edges are crisp and golden.
While cauliflower roasts, prepare the buffalo sauce by first grating the garlic into a large mixing bowl. Add honey and buffalo sauce and whisk together until well combined.
Remove cauliflower from oven and immediately toss into the bowl with the prepared buffalo sauce. Stir together to coat the cauliflower in the sauce. Serve immediately.